ABSTRACT
As the first line of defense between the intestinal environment and the outside world， the intestinal mucosal barrier is essential for maintaining the intestinal homeostasis. The intestinal mucosal barrier injury will change the intestinal permeability and allow bacterial translocation and the entry of endotoxins into blood， thus triggering a series of inflammatory responses， followed by the injury of related tissues and the aggravation of primary diseases. The spleen， the acquired foundation， is responsible for maintaining the internal and external balance of the body and resisting external evils. Its physiological function is similar to that of the intestinal mucosal barrier. Spleen deficiency easily leads to intestinal mucosal barrier dysfunction. Therefore， replenishing Qi， invigorating spleen， and restoring the efficacy of spleen and stomach qi in defensing and governing transportation and transformation are the keys to prevent and treat intestinal mucosal barrier injury. In recent years， studies have shown that the spleen-invigorating Chinese medicinals repair the intestinal mucosal injury by promoting the expression of intestinal epithelial tight junction proteins， regulating the intestinal immune function， microbial flora， and metabolites， and supplementing the intestinal nutrition， enabling them to gradually become a research hotspot. After reviewing the relevant articles published in China and abroad， this paper expounded the common syndrome types of traditional Chinese medicine （TCM）， the changes in intestinal mucosal barrier induced by spleen deficiency， the repairing effects of spleen-invigorating Chinese medicinals on intestinal mucosal barrier injury， in order to provide some clues for the research on the treatment of intestinal mucosal barrier dysfunction-related diseases with spleen-invigorating Chinese medicinals.
ABSTRACT
Objective: To analyze and explore the application of duable-pass optical quality analysis system(OQAS) on the evaluation of visual quality for patients with high myopia complicated with cataract who received intraocular lens implantation. Methods: The documents of 93 patients with high myopia complicated with cataract were collected in the retrospective analysis. And all of patients received ultrasonic emulsification and intraocular lens implantation. And then the visual situation and the changes of PSF, OSI, MTF, MTFcutoff, SR, OV100%, OV20%and OV9%were evaluated by using double-pass OQAS at three points included pre-operation, 1week of post-operation and 1month of post-operation. Results: After treatment, the visual situation of patients were significantly improved, and the differences of visual situations among pre-operation, 1 week of post-operation and 1 month of post operation were significant (F=6.831, P<0.05). And the differences of OSI, PSF and OV9%between the before and after treatment were significant (F=6.732, F=9.102, F=5.029, P<0.05), respectively. While the differences of MTFcutoff, SR, OV100%and OV20% between the two groups were no significant. Under the conditions of 5 cpd and 10 cpd of MTF, the differences of MTF among pre-operation, 1 week post operation and 1month post operation were significant (F=8.029, F=4.039, P<0.05), respectively. Besides, at 1 week post-operation and 1month post-operation, the differences among 5cpd, 10cpd and 15cpd were significant(F=7.829, F=6.921, P<0.05), respectively. Conclusion: After the patients with high myopia complicated with cataract receive intraocular lens implantation of ultrasonic emulsification, the visual analysis system of dual channel can preferably evaluate the visual quality of patients, and can objectively reflect aberration, scattering and diffraction, etc. Therefore, it is worthy to be popularized and applied.